|Attacks||Locks on, then approach then explode|
Lost Soul are large flying skulls that are usually scattered around the later Hell missions. They are Hell's equivalent of Homing Missiles. They will always explode upon destruction. Lost Souls can also be created by a Soul Catcher, Skull Turret, and a Bone Wurm. They appear with flames and when spotting a bro, their eyes will become red and they will aggressively pursue the bro unless either is down.
On certain occasions, the Lost Soul will not instantly explode, but will simply fall and explode a little later, it can catch players off-guard if they are not careful.